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Longevity Practice

Compression of morbidity

James Fries's 1980 paper and the longevity goal worth wanting

The goal of medicine, Fries argued, should not be to extend life but to compress the period of late-life disease into as short a window as possible. Forty-five years on, the framework remains the right way to think about the longevity project — and a useful corrective to the language of "anti-ageing".

#ageing #healthspan #mortality #biomarkers

By Mick

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Longevity Practice

What knowledge workers get wrong about training

The cardio-versus-strength false dichotomy and the minimum effective dose

For people whose job involves sitting and thinking, exercise tends to be approached as an aesthetic project or a discharge of accumulated stress. Neither lens captures what the evidence suggests should actually be on the calendar.

#exercise #zone-2 #deep-work #vo2-max #hormesis

By Mick

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Longevity Practice

A framework for evaluating supplement claims

Three tiers, one worked example, and a way to keep one's wallet shut

The supplement industry generates tens of billions of dollars in revenue from claims that range from well-evidenced to fabricated. A three-tier framework helps separate what is worth taking, what is worth experimenting with, and what is worth ignoring entirely.

#supplements #evidence #mental-models #biomarkers #habits

By Mick

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Longevity Practice

VO2 max and the all-cause mortality curve

One of the strongest signals in longevity science, and what to do about it

Across multiple large cohorts, cardiorespiratory fitness emerges as one of the most powerful predictors of all-cause mortality — comparable in effect size to smoking. The data is unusually clean. The training implications are unusually concrete.

#vo2-max #mortality #zone-2 #exercise #biomarkers #healthspan

By Mick

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